Antonio Conte says Chelsea must seize the chance to move a step closer to winning the Premier League when the leaders face Arsenal in Saturday's crucial summit meeting.
Conte's side are nine points clear at the top with 15 games remaining and victory over title rivals Arsenal at Stamford Bridge would be a significant moment in the race to replace Leicester as English champions.
Beating the third-placed Gunners would move Chelsea 12 points clear of Arsene Wenger's side, as well as sending a message to the chasing pack that the Blues are determined to hold onto their lead.
Conte would dearly love to see off Arsenal after the north Londoners' 3-0 victory at the Emirates Stadium in their previous meeting this season.
That was the most chastening moment of Conte's first season at Chelsea and the Italian, whose side have lost only one of their last 17 league games, said: "There are 15 games remaining and 45 points. Now we must focus on Arsenal.
"They are a great team who can fight for the title. Don't forget we lost 3-0 away.
"This could be a good chance for us to show that the second part of the season we are a totally different team if you compare us to the previous game.
"It is a good chance for us. We play at home, which is very important, but it will be a really tough game."
With Chelsea held to a 1-1 draw at Liverpool on Tuesday, Arsenal squandered an opportunity to close the gap as they crashed to a shock 2-1 home defeat against Watford.
Wenger's side haven't won at the Bridge since 2011 and they must end that barren run to remain in the title hunt.
Arsenal goalkeeper Petr Cech, who won four league titles during his time at Chelsea, said of the Watford defeat: "It was a huge setback because we wanted to put ourselves in a better position going into the weekend.
"I always say that at this level you cannot play 80 minutes, or 85. You have to play 90 minutes with full concentration and everybody on top of their game."
Second-placed Tottenham host Middlesbrough as they try to regain ground on Chelsea after drawing their last two matches.
"With the mentality we have here, we would be upset to finish in the same position as last season," said Tottenham's Eric Dier, whose team lost out to Leicester in the title battle last term.
"We want to be better and we want to show it. Everyone wants to reach the very top."
At the King Power Stadium both managers will be in the spotlight as troubled Leicester and spluttering Manchester United clash.
Leicester's fairytale title triumph already seems like a distant memory as Claudio Ranieri's team find themselves just two points above the relegation zone after three successive defeats.
Fixtures
(1500 GMT unless stated)
Saturday
Chelsea v Arsenal (1230 GMT), Crystal Palace v Sunderland, Everton v Bournemouth, Hull v Liverpool, Southampton v West Ham, Tottenham v Middlesbrough (1730 GMT), Watford v Burnley, West Brom v Stoke
Sunday
Leicester v Manchester United (1600 GMT), Manchester City v Swansea (1330 GMT)